Efficient Strategy to Identify Gene-Gene Interactions and Its Application to Type 2 Diabetes
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چکیده
منابع مشابه
Efficient Strategy to Identify Gene-Gene Interactions and Its Application to Type 2 Diabetes
Over the past decade, the detection of gene-gene interactions has become more and more popular in the field of genome-wide association studies (GWASs). The goal of the GWAS is to identify genetic susceptibility to complex diseases by assaying and analyzing hundreds of thousands of single-nucleotide polymorphisms. However, such tests are computationally demanding and methodologically challenging...
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Gene-Environment and Gene-Treatment Interactions in Type 2 Diabetes
Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does appear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing susceptibility genes hav...
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Although genome-wide association studies (GWAS) have identified a significant number of single-nucleotide polymorphisms (SNPs) associated with many complex human traits, the susceptibility loci identified so far can explain only a small fraction of the genetic risk. Among other possible explanations, the lack of a comprehensive examination of gene-gene interaction (G×G) is often considered a so...
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ژورنال
عنوان ژورنال: Genomics & Informatics
سال: 2016
ISSN: 2234-0742
DOI: 10.5808/gi.2016.14.4.160